Nifestad

Nifestad may be available in the countries listed below.

Ingredient matches for Nifestad

Nifedipine

Nifedipine is reported as an ingredient of Nifestad in the following countries:

• Philippines

International Drug Name Search

Fluocinolone Acetonide topical

Class: Anti-inflammatory Agents
ATC Class: D07AC04
VA Class: DE200
CAS Number: 67-73-2
Brands: Capex, Derma-Smoothe/FS, Lidex, Lidex-E, Synalar, Synemol

Introduction

Synthetic fluorinated corticosteroids.^{b c d e}

Uses for Fluocinolone Acetonide

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.^{a c d e f}

Generally most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, anogenital pruritus, psoriasis, late phase of allergic contact dermatitis, inflammatory phase of xerosis).^a

Topical therapy generally preferred over systemic therapy; fewer associated adverse systemic effects.^a

Topical therapy generally only controls manifestations of dermatoses; eliminate cause if possible.^a

Topical efficacy may be increased by using a higher concentration or occlusive dressing therapy.^a (See Administration with Occlusive Dressing under Dosage and Administration.)

Response may vary from one topical corticosteroid preparation to another.^a

Anti-inflammatory activity may vary considerably depending on the vehicle, drug concentration, site of application, disease, and individual patient.^a

Fluocinonide 0.05% cream, ointment, and gel are considered to have high-range potency.^a

Fluocinolone acetonide 0.025% ointment is considered to have high-range potency.^a

Fluocinolone acetonide 0.025% cream is considered to have medium potency.^a

Fluocinolone acetonide 0.01% shampoo is considered to have low–medium potency.^f

Fluocinolone acetonide 0.01% solution is considered to have low potency.^a

Fluocinolone Acetonide Dosage and Administration

General

• 
  

  Consider location of the lesion and the condition being treated when choosing a dosage form.^a

  
  


• 
  

  Creams are suitable for most dermatoses, but ointments also may provide some occlusion and usually are used for the treatment of dry, scaly lesions.^a

  
  


• 
  

  Lotions probably are best for treatment of weeping eruptions, especially in areas subject to chafing (e.g., axilla, foot, groin).^a Lotions, gels, and aerosols may be used on hairy areas, particularly the scalp.^a

  
  


• 
  

  Formulation affects percutaneous penetration and subsequent activity; extemporaneous preparation or dilution of commercially available products with another vehicle may decrease effectiveness.^a

  
  


• 
  

  Patients applying a topical corticosteroid to a large surface area and/or to areas under occlusion should be evaluated periodically for evidence of hypothalamic-pituitary-adrenal (HPA)-axis suppression by appropriate endocrine testing (e.g., ACTH stimulation, plasma cortisol, urinary free cortisol).^{c d e f} (See Hypothalamic-Pituitary-Adrenal Axis Suppresion and also Systemic Effects, under Cautions.)

  
  

Administration

Topical Administration

For dermatologic use only; avoid contact with eyes.^{c d e f} If such contact occurs, flush the affected eye(s) with copious amounts of water.^{e f}

The area of skin to be treated may be thoroughly cleansed before topical application to reduce the risk of infection; however, some clinicians believe that, unless an occlusive dressing is used, cleansing of the treated area is unnecessary and may be irritating.^a

Apply cream, gel, ointment, or solution sparingly in a thin film and rub gently into the affected area.^{b c d e}

Fluocinolone acetonide shampoo should be prepared by a pharmacist at the time of dispensing; contents of the 12-mg capsule should be mixed with the shampoo base supplied by the manufacturer.^{b f}

The extemporaneously prepared shampoo must be shaken well prior to administration.^{b f}

Apply ≤30 mL of shampoo to the scalp once daily, lather, and allow to remain on the scalp for about 5 minutes;^b then rinse the hair and scalp thoroughly with water.^b

After a favorable response is achieved, frequency of application or concentration (strength) may be decreased to the minimum necessary to maintain control and to avoid relapse; discontinue if possible.^a

Administration with Occlusive Dressing

Occlusive dressings may be used for severe or resistant dermatoses (e.g., psoriasis).^{b c d e} (See Occlusive Dressings under Cautions.) However, the manufacturer states that fluocinolone acetonide shampoo should not be used with occlusive dressings; treated areas of the scalp should not be bandaged or otherwise covered or wrapped as to be occlusive, unless directed by a clinician.^b

Soak or wash the affected area to remove scales; apply a thin film of cream, lotion, or ointment; rub gently into the lesion; and apply another thin film.^a Cover affected area with a thin, pliable plastic film and seal it to adjacent normal skin with adhesive tape or hold in place with a gauze or elastic bandage.^a

If affected area is moist, incompletely seal the edges of the plastic film or puncture the film to allow excess moisture to escape.^a For added moisture in dry lesions, apply cream, ointment, or lotion and cover with a dampened cloth before the plastic film is applied or briefly soak the affected area in water before application of the drug and plastic film.^a

Thin polyethylene gloves may be used on the hands and fingers, plastic garment bags may be used on the trunk or buttocks, a tight shower cap may be used for the scalp, or whole-body suits may be used instead of plastic film to provide occlusion.^a

Frequency of occlusive dressing changes depends on the condition being treated; cleansing of the skin and reapplication of the corticosteroid are essential at each dressing change.^a

Occlusive dressing usually is left in place for 12–24 hours and therapy is repeated as needed.^a Although occlusive dressing may be left in place for 3–4 days at a time in resistant conditions, most clinicians recommend intermittent use of occlusive dressings for 12 hours daily to reduce the risk of adverse effects (particularly infection) and systemic absorption and for greater convenience.^a

The drug and an occlusive dressing may be used at night, and the drug or a bland emollient may be used without an occlusive dressing during the day.^a

In patients with extensive lesions, sequential occlusion of only one portion of the body at a time may be preferable to whole-body occlusion.^a (See Occlusive Dressings under Cautions.)

Dosage

Available as fluocinolone acetonide and fluocinonide; dosage expressed in terms of the salt and the base, respectively.^{c d e f}

Pediatric Patients

Administer the least amount of topical preparations that provides effective therapy.^{a c d e} (See Pediatric Use under Cautions.)

Corticosteroid-responsive Dermatoses

Topical

Apply cream, gel, ointment, or solution sparingly 2–4 times daily depending on the severity of the condition.^{b c d e}

For the treatment of moderate to severe atopic dermatitis in children ≥2 years of age, apply a thin film of fluocinolone acetonide 0.01% topical oil twice daily to affected areas for no longer than 4 weeks.^a

Adults

Corticosteroid-responsive Dermatoses

Topical

Apply cream, gel, ointment, or solution sparingly 2–4 times daily depending upon severity of condition.^{b c d e}

For the treatment of atopic dermatitis, apply fluocinolone acetonide 0.01% topical oil as a thin film 3 times daily.^b

For the treatment of psoriasis of the scalp, apply a thin film of fluocinolone acetonide 0.01% topical oil to wet or dampened hair and scalp, massage well, and cover with the manufacturer-supplied shower cap.^b Allow oil to remain on the scalp overnight or for a minimum of 4 hours following application before being washed off with regular shampoo and rinsed thoroughly with water.^b

For the treatment of seborrheic dermatitis of the scalp, apply ≤30 mL of fluocinolone acetonide 0.01% shampoo to the scalp once daily.^b

Prescribing Limits

Pediatric Patients

Corticosteroid-responsive Dermatoses

Topical

For the treatment of moderate to severe atopic dermatitis in children ≥2 years of age, maximum 4 weeks of therapy.^a

Adults

Corticosteroid-responsive Dermatoses

Topical

For the treatment of seborrheic dermatitis of the scalp, maximum 30 mL of fluocinolone acetonide 0.01% shampoo applied to the scalp once daily.^b

Cautions for Fluocinolone Acetonide

Contraindications

• 
  

  Known hypersensitivity to fluocinolone acetonide, fluocinonide, or any ingredient in the formulation.^{c d e f}

  
  

Warnings/Precautions

Sensitivity Reactions

Allergic contact dermatitis may manifest as failure to heal rather than irritation as occurs with other topical preparations that do not contain corticosteroids; confirm with diagnostic patch testing.^f

Peanut Hypersensitivity

Fluocinolone acetonide 0.01% topical oil is formulated with 48% refined peanut oil.^b Use this formulation with caution in individuals with known hypersensitivity to peanuts.^b If wheal and flare type reactions (which may be limited to pruritus) or other manifestations of hypersensitivity reactions develop, discontinue use of this formulation and institute appropriate therapy.^b

General Precautions

Hypothalamic-Pituitary-Adrenal Axis Suppression.

Topically applied corticosteroids can be absorbed in sufficient amounts to reversibly suppress the HPA axis.^{c d e f}

Perform periodic HPA-axis evaluation by appropriate testing (e.g., ACTH stimulation, morning plasma cortisol, urinary free cortisol), especially in patients applying a topical corticosteroid to a large surface area or to areas under occlusion.^{c d e f}

If HPA-axis suppression occurs, withdraw the drug, reduce the frequency of application, and/or substitute a less potent corticosteroid.^{a c d e f}

HPA-axis function recovery generally is prompt and complete following drug discontinuance.^{a c d e f}

Rarely, glucocorticosteroid insufficiency may require systemic corticosteroid therapy.^{a c d e f}

Systemic Effects

Systemic absorption following topical administration may result in manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients.^{a c d e f}

Risk of adverse systemic effects increased with use of a high-potency topical corticosteroid, especially if applied to large areas of the body, for prolonged periods of time, with an occlusive dressing, and/or concurrently with other corticosteroid-containing preparations.^a

Infants and children may be more susceptible to adverse systemic effects.^{a c d e} (See Pediatric Use under Cautions.)

Local Effects

Possible adverse local reactions (e.g., irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, striae, miliaria);^{a c f} may occur more frequently with the use of occlusive dressings, especially with prolonged therapy.^a

Prolonged use of topical corticosteroids may cause atrophy of the epidermis and subcutaneous tissue;^{a c d e} these effects are most likely to occur (even with short-term use) in intertriginous (e.g., axilla, groin), flexor, and facial areas.^{a e}

If irritation occurs, discontinue drug and institute appropriate therapy.^{c d e f}

Skin Infection

If concurrent skin infection is present or develops, initiate appropriate anti-infective therapy.^{a c d e f} If infection does not respond promptly, discontinue topical corticosteroid therapy until the infection has been controlled.^{c d e}

When topical corticosteroids and topical anti-infectives are used concomitantly, consider that the corticosteroid may mask clinical signs of bacterial, fungal, or viral infections; prevent recognition of ineffectiveness of the anti-infective; or suppress hypersensitivity reactions to ingredients in the formulation.^{a g} In addition, consider the cautions, precautions, and contraindications associated with the anti-infective.^{a g}

Do not use occlusive dressings in patients with primary skin infection.^a

Some manufacturers state that topical corticosteroids are contraindicated in patients with tuberculosis of the skin, dermatologic fungal infections, and cutaneous or systemic viral infection (including vaccinia and varicella and herpes simplex of the eye or adjacent skin).^a However, most clinicians believe topical corticosteroids can be used with caution if the infection is treated.^a

Occlusive Dressings

Adverse systemic corticosteroid effects may occur with use of occlusive dressings on large areas of the body and for prolonged periods of time; monitor accordingly.^{a c} (See Hypothalamic-Pituitary-Adrenal Axis Suppression and also Systemic Effects, under Cautions.)

Adverse local reactions may occur more frequently with the use of occlusive dressings, especially with prolonged therapy.^{a c} (See Local Effects under Cautions.)

Do not use occlusive dressings on weeping or exudative lesions.^a

Do not use occlusive dressings in patients with primary skin infection.^a

Remove occlusive dressings covering large areas if body temperature increases; thermal homeostasis may be impaired.^a

Use plastic occlusive material with care to avoid the risk of suffocation.^a

Specific Populations

Pregnancy

Category C.^{c d e f}

Lactation

Not known whether topical fluocinolone acetonide or fluocinonide is distributed into milk.^{c d e f} Caution advised if these preparations are used.^{c d e f}

Pediatric Use

Safety and efficacy of fluocinolone actonide shampoo not established.^{b f}

Safety and efficacy of fluocinolone acetonide 0.01% topical oil in the management of moderate to severe stable atopic dermatitis in children ≥2 years of age have been established.^b However, the long-term safety of the topical oil in pediatric patients has not been established.^b

Tight-fitting diapers or plastic pants should not be used on a child being treated with the drug in the diaper area, since they may constitute occlusive dressings.^{c d e}

The topical oil should not be applied to the face or diaper area.^b

Children are more susceptible to topical corticosteroid-induced HPA-axis suppression and Cushing’s syndrome than mature individuals because of a greater skin surface area-to-body weight ratio,^{a c d e} especially when topical corticosteroids are applied to >20% of body surface area.^a The risk of adrenal suppression appears to increase with decreasing age.^a (See Systemic Effects under Cautions.)

Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol concentrations, and lack of response to corticotropin (ACTH) stimulation.^{a c d e f}

Children also are at greater risk of glucocorticosteroid insufficiency during and/or after withdrawal of treatment.^a

Intracranial hypertension has occurred in children; manifestations include bulging fontanelles, headaches, and bilateral papilledema.^{a c d e f}

Striae has been reported in children treated inappropiately with topical corticosteroids.^{a f}

Topical corticosteroid therapy in children should be limited to the minimum amount necessary for therapeutic efficacy; chronic topical corticosteroid therapy may interfere with growth and development.^a

Common Adverse Effects

Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, miliaria.^{c d e f}

Interactions for Fluocinolone Acetonide

Specific Drugs and Laboratory Tests

Drug or Test	Interaction
Corticosteroids	Potential pharmacologic interaction with other corticosteroid-containing preparationsa
Nitroblue-tetrazolium test for bacterial infection	Concurrent use of corticosteroids reportedly may result in false-negative resultsa

Fluocinolone Acetonide Pharmacokinetics

Absorption

Bioavailability

Topically applied fluocinolone acetonide and fluocinonide can be absorbed through normal intact skin.^{a c d e f}

Percutaneous penetration can be altered by using different vehicles.^{c d e f}

Percutaneous penetration also can be increased by use of occlusive dressings and by presence of inflammation and/or other disease of the epidermal barrier (e.g., psoriasis, eczema).^{a c d e}

Distribution

Extent

Not known whether topical fluocinolone acetonide or fluocinonide is distributed into milk.^{c d e f}

Elimination

Metabolism

Once absorbed through the skin, topically applied corticosteroids are metabolized primarily in the liver.^{c d e}

Elimination Route

Topical corticosteroids and metabolites are excreted by the kidneys and, to a lesser extent, in bile.^{c d e}

Stability

Storage

Topical

Cream, Gel, Ointment, Solution, and Shampoo

Tight containers^{b f} at 15–30°C.^{c d f} Do not freeze.^b Protect from excessive heat (above 40°C).^e

The extemporaneously prepared shampoo is stable for 3 months from the time of compounding.^b

ActionsActions

• 
  

  Produces anti-inflammatory, antipruritic, and vasoconstrictor actions, possibly resulting in part from steroid receptor binding.^a

  
  


• 
  

  Precise mechanism of action for topical anti-inflammatory activity is unknown; therapeutic benefit in the management of corticosteroid-responsive dermatoses mediated primarily through anti-inflammatory, antipruritic, and vasoconstrictive actions.^{a c d e f}

  
  


• 
  

  Anti-inflammatory effects may occur through induction of phospholipase A₂ inhibitory proteins (lipocortins); decreased arachidonic acid release from membrane phospholipids.^f Decreased arachidonic acid precursors may downregulate biosynthesis of potent inflammatory mediators (e.g., prostaglandins, leukotrienes).^f

  
  

Advice to Patients

• 
  

  Importance of using only as directed, only for the disorder for which it was prescribed, and for no longer than prescribed; avoid contact with the eyes and only apply externally as directed.^{a c d e f} (See Topical Administration under Dosage and Administration.)

  
  


• 
  

  Importance of informing patients that treated areas of the skin should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by a clinician.^{c d e f}

  
  


• 
  

  Importance of reporting any local adverse reactions, especially those occurring under occlusive bandage, to a clinician.^{c d e f}

  
  


• 
  

  Importance of informing parents of children that if fluocinolone topical preparations are applied in the diaper area, that tight-fitting diapers or plastic pants should not be used since they may act as an occlusive dressing.^{c d e}

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.

  
  


• 
  

  Importance of informing patients of other important precautionary information. (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Fluocinolone Acetonide

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Topical	Cream	0.01%*
		0.025%*	Synalar (with parabens and propylene glycol)	Medicis
			Synemol Emollient Cream	Medicis
	For shampoo	0.01%	Capex Shampoo	Galderma
	Oil	0.01%	Derma-Smoothe/FS (with isopropyl alcohol)	Hill
	Ointment	0.025%*	Fluocinolone Acetonide Ointment	Fougera, G&W, Major, Teva
			Synalar	Medicis
	Solution	0.01%*	Synalar (with propylene glycol)	Medicis

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Fluocinonide

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Topical	Cream	0.05%*	Fluocinonide E Emollient Cream	Alpharma, IVAX, Taro, Teva
			Lidex (with propylene glycol)	Medicis
			Lidex-E Emollient Cream (with propylene glycol)	Medicis
	Gel	0.05%*	Fluocinonide Gel	Fougera, Taro, Teva
			Lidex Gel (with propylene glycol)	Medicis
	Ointment	0.05%*	Lidex (with propylene glycol)	Medicis
	Solution	0.05%*	Lidex (with alcohol 35% and propylene glycol)	Medicis

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Fluocinonide 0.05% Cream (TEVA PHARMACEUTICALS USA): 15/$11.99 or 45/$22.97

Fluocinonide 0.05% Cream (TEVA PHARMACEUTICALS USA): 30/$12.99 or 90/$36.97

Fluocinonide 0.05% Cream (FOUGERA): 60/$14.99 or 180/$26.97

Fluocinonide 0.05% Gel (FOUGERA): 15/$17.99 or 45/$49.97

Fluocinonide 0.05% Gel (FOUGERA): 60/$37.99 or 180/$105.97

Fluocinonide 0.05% Gel (TARO): 30/$23.99 or 90/$67.97

Fluocinonide 0.05% Ointment (TARO): 15/$19.99 or 45/$54.97

Fluocinonide 0.05% Ointment (TARO): 60/$33.99 or 180/$90.96

Fluocinonide 0.05% Ointment (TEVA PHARMACEUTICALS USA): 30/$23.99 or 90/$67.97

Fluocinonide 0.05% Solution (TARO): 20/$23.99 or 40/$39.98

Fluocinonide 0.05% Solution (TEVA PHARMACEUTICALS USA): 60/$22.99 or 180/$64.99

Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 60/$17.99 or 180/$50.96

Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 15/$16.99 or 45/$36.97

Fluocinonide-E 0.05% Cream (TEVA PHARMACEUTICALS USA): 30/$15.99 or 90/$41.97

Vanos 0.1% Cream (MEDICIS): 60/$280.99 or 180/$780.97

Vanos 0.1% Cream (MEDICIS): 30/$179.99 or 90/$499.97

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2006. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

a. AHFS drug information 2005 McEvoy GK, ed. Topical Corticosteroids General Statement. Bethesda, MD: American Society of Health-System Pharmacists; 2005:3425-8.

b. AHFS drug information 2005. McEvoy GK, ed. Fluocinolone Acetonide/Fluocinonide. Bethesda, MD: American Society of Health-System Pharmacists; 2005:3432-3.

c. Taro. Fluocinonide gel 0.05% prescribing information. Hawthorne, NY; 1997 Jan.

d. Taro. Fluocinonide ointment 0.05% prescribing information. Hawthorne, NY; 1998 Aug.

e. Taro. Fluocinonide topical solution 0.05% prescribing information. Bramalea, ON, Canada; 1998 Feb.

f. Hill. Capex (fluocinolone acetonide) shampoo 0.01% prescribing information. Sanford, FL; 2000 Jul.

g. AHFS drug information 2006. McEvoy GK, ed. Neomycin Sulfate. Bethesda, MD: American Society of Health-System Pharmacists; 2006: 2739-40.

More Fluocinolone Acetonide topical resources

• Fluocinolone Acetonide topical Use in Pregnancy & Breastfeeding
• Fluocinolone Acetonide topical Drug Interactions
• Fluocinolone Acetonide topical Support Group
• 3 Reviews for Fluocinolone Acetonide - Add your own review/rating

Compare Fluocinolone Acetonide topical with other medications

• Atopic Dermatitis
• Dermatitis
• Lichen Sclerosus

pyridoxine

Generic Name: pyridoxine (vitamin B6) (PIR ih DOX een)

Brand names: Vitamin B6, Vitelle Nestrex

What is pyridoxine?

Pyridoxine is vitamin B6. Vitamins are naturally occurring substances necessary for many processes in the body. Pyridoxine is important in the breakdown of protein, fats, and carbohydrates from foods into products needed by the body.

Pyridoxine is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is used to treat some types of seizure in babies.

Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.

Pyridoxine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about pyridoxine?

You should not use pyridoxine if you have ever had an allergic reaction to it.

Ask a doctor or pharmacist before taking pyridoxine if you have any medical conditions, if you take other medications or herbal products, or if you are allergic to any drugs or foods.

Before you receive injectable pyridoxine, tell your doctor if you have kidney disease or heart disease. Pyridoxine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

What should I discuss with my healthcare provider before taking pyridoxine?

You should not use pyridoxine if you have ever had an allergic reaction to it.

Ask a doctor or pharmacist if it is safe for you to take this medicine if:

• 
  

  you have any other medical conditions;

  
  


• 
  

  you take other medications or herbal products; or

  
  


• 
  

  you are allergic to any drugs or foods.

  
  

To make sure you can safely receive injectable pyridoxine, tell your doctor if you have heart disease or kidney disease. FDA pregnancy category A. Pyridoxine is not expected to harm an unborn baby. Your pyridoxine dose needs may be different during pregnancy. Do not take pyridoxine without medical advice if you are pregnant or plan to become pregnant. Pyridoxine can pass into breast milk. Your dose needs may be different while you are nursing. High doses of this medication may harm a nursing baby. Do not take pyridoxine without medical advice if you are breast-feeding a baby.

How should I take pyridoxine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Injectable pyridoxine is injected into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Never use more than the recommended dose of pyridoxine.

The recommended dietary allowance of pyridoxine increases with age. Follow your healthcare provider's instructions. You may also consult the National Academy of Sciences "Dietary Reference Intake" or the U.S. Department of Agriculture's "Dietary Reference Intake" (formerly "Recommended Daily Allowances" or RDA) listings for more information.

Pyridoxine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition. Store at room temperature away from moisture and heat.

See also: Pyridoxine dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking pyridoxine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Pyridoxine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  decreased sensation to touch, temperature, and vibration;

  
  


• 
  

  loss of balance or coordination;

  
  


• 
  

  numbness in your feet or around your mouth;

  
  


• 
  

  clumsiness in your hands; or

  
  


• 
  

  feeling tired.

  
  

Less serious side effects may include:

• 
  

  nausea;

  
  


• 
  

  headache;

  
  


• 
  

  drowsiness; or

  
  


• 
  

  mild numbness or tingling.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pyridoxine Dosing Information

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis:
Cycloserine: 100 to 300 mg/day orally in divided doses.
Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.
Oral contraceptives: 25 to 30 mg/day orally.

Acute Intoxication:
Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.

Usual Adult Dose for Dietary Supplement:

Pyridoxine Deficiency:
10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.

Usual Adult Dose for Anemia:

Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.

If therapeutic response is not obtained after 1 to 2 months of pyridoxine therapy, a different therapy should be considered.

Usual Adult Dose for Nausea/Vomiting:

Nausea and vomiting of Pregnancy:
25 mg orally every 8 hours.

Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :
Treatment: 10 to 50 mg/day.
Prophylaxis: 1 to 2 mg/kg/day

Acute Intoxication:

Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: Acute ingestion of known amount: Initial: A total dose of pyridoxine equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining pyridoxine over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.

Usual Pediatric Dose for Dietary Supplement:

Pyridoxine Deficiency:
5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.

Usual Pediatric Dose for Seizures:

Pyridoxine-dependent seizures:
10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.

What other drugs will affect pyridoxine?

There may be other drugs that can interact with pyridoxine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More pyridoxine resources

• Pyridoxine Side Effects (in more detail)
• Pyridoxine Dosage
• Pyridoxine Use in Pregnancy & Breastfeeding
• Pyridoxine Drug Interactions
• Pyridoxine Support Group
• 1 Review for Pyridoxine - Add your own review/rating

• pyridoxine Oral, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Pyridoxine Hydrochloride Monograph (AHFS DI)

Compare pyridoxine with other medications

• Anemia
• Dietary Supplementation
• Drug Induced Vitamin/Mineral Deficiency
• Nausea/Vomiting
• Seizures

Where can I get more information?

• Your pharmacist can provide more information about pyridoxine.

See also: pyridoxine side effects (in more detail)

Lizpion

Lizpion may be available in the countries listed below.

Ingredient matches for Lizpion

Lincomycin

Lincomycin hydrochloride monohydrate (a derivative of Lincomycin) is reported as an ingredient of Lizpion in the following countries:

• Japan

International Drug Name Search

Prograf Intravenous

Generic Name: tacrolimus (Intravenous route)

ta-KROE-li-mus

Intravenous route(Solution)

Increased susceptibility to infection and the possible development of lymphoma and other malignancies may result from immunosuppression. Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe, and they should have complete information requisite for the follow-up of the patient .

Commonly used brand name(s)

In the U.S.

• Prograf

Available Dosage Forms:

• Solution

Therapeutic Class: Immune Suppressant

Pharmacologic Class: Calcineurin Inhibitor

Uses For Prograf

Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (e.g., kidney, liver, or heart). This medicine may be used with steroids, azathioprine (Imuran®), or mycophenolate mofetil (Cellcept®). Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although not specifically included in the product labeling, tacrolimus is used in certain patients with the following medical conditions:

• Bone marrow transplant.


• Pancreas transplant.

Before Using Prograf

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tacrolimus injection in children with liver transplants.

Appropriate studies have not been performed on the relationship of age to the effects of tacrolimus injection in children with kidney and heart transplants. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tacrolimus injection in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving tacrolimus injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac


• Acemetacin


• Alclofenac


• Amikacin


• Amiloride


• Amiodarone


• Apazone


• Atazanavir


• Bacillus of Calmette and Guerin Vaccine, Live


• Basiliximab


• Benoxaprofen


• Bromfenac


• Bufexamac


• Carbamazepine


• Carprofen


• Caspofungin


• Cisplatin


• Clometacin


• Clonixin


• Colchicine


• Crizotinib


• Cyclosporine


• Darunavir


• Dexketoprofen


• Dibekacin


• Diclofenac


• Diflunisal


• Dipyrone


• Droxicam


• Efavirenz


• Etodolac


• Etofenamate


• Etravirine


• Felbinac


• Fenbufen


• Fenoprofen


• Fentiazac


• Floctafenine


• Flufenamic Acid


• Flurbiprofen


• Gentamicin


• Ibuprofen


• Indomethacin


• Indoprofen


• Infliximab


• Isoxicam


• Itraconazole


• Kanamycin


• Ketoprofen


• Ketorolac


• Lornoxicam


• Measles Virus Vaccine, Live


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Mumps Virus Vaccine, Live


• Nabumetone


• Naproxen


• Nefazodone


• Nelfinavir


• Neomycin


• Netilmicin


• Niflumic Acid


• Nimesulide


• Oxaprozin


• Oxyphenbutazone


• Pazopanib


• Phenobarbital


• Phenylbutazone


• Phenytoin


• Pirazolac


• Piroxicam


• Pirprofen


• Poliovirus Vaccine, Live


• Posaconazole


• Propyphenazone


• Proquazone


• Rifabutin


• Rifampin


• Rotavirus Vaccine, Live


• Rubella Virus Vaccine, Live


• Sirolimus


• Smallpox Vaccine


• Spironolactone


• St John's Wort


• Streptomycin


• Sulindac


• Suprofen


• Telaprevir


• Tenidap


• Tenofovir


• Tenoxicam


• Tiaprofenic Acid


• Tobramycin


• Tolmetin


• Triamterene


• Typhoid Vaccine


• Varicella Virus Vaccine


• Vemurafenib


• Voriconazole


• Yellow Fever Vaccine


• Zomepirac

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amprenavir


• Chloramphenicol


• Clarithromycin


• Clotrimazole


• Dalfopristin


• Danazol


• Diltiazem


• Erythromycin


• Fluconazole


• Fosphenytoin


• Ketoconazole


• Metoclopramide


• Metronidazole


• Mibefradil


• Nevirapine


• Nifedipine


• Quinupristin


• Rifapentine


• Ritonavir


• Saquinavir


• Schisandra sphenanthera


• Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to polyoxyl 60 hydrogenated castor oil—Should not be used in patients with this condition.

• Diabetes or


• Hyperkalemia (high potassium in the blood) or


• Hypertension (high blood pressure) or


• Myocardial hypertrophy (heart is larger than normal), history of or


• Paresthesias (numbness or tingling in the hands, arms, legs, or feet), history of or


• Seizures (convulsions), history of or


• Tremors—Use with caution. May make these conditions worse.

• Infection, active (eg, bacteria, fungus, or virus)—May decrease your body's ability to fight an infection.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of Prograf

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

You will only receive this medicine for a few days. Then your doctor will switch you to the oral (by mouth) form of tacrolimus.

This medicine comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using Prograf

It is very important that your doctor check your progress while you are receiving this medicine to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Tacrolimus injection may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you have itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

This medicine may increase your risk of getting skin cancer or cancer of the lymph system (lymphoma). Talk to your doctor if you have concerns about this risk.

This medicine may increase your risk of developing infections. Avoid being near people who are sick while you are receiving this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start using this medicine. Tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.

While you are being treated with tacrolimus, and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor's approval. Tacrolimus may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.

This medicine may increase your risk for developing a rare and serious virus infection with the BK polyoma virus. This virus may affect how your kidneys work and cause a transplanted kidney to fail. Check with your doctor right away if you are having more than one of these symptoms: bloody urine; a decreased frequency or amount of urine; increased thirst; loss of appetite; lower back or side pain; nausea; swelling of the face, fingers, or lower legs; trouble with breathing; unusual tiredness or weakness; vomiting; or weight gain.

This medicine may increase your risk of developing a serious and rare brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you are having more than one of these symptoms: vision changes, loss of coordination, clumsiness, confusion, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.

This medicine may cause serious nervous system problems. Tell your doctor right away if you have the following symptoms while using this medicine: blurred vision, dizziness, headache, mental changes, seizures, high blood pressure, or a fast heartbeat.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.

Tacrolimus may cause a condition called pure red cell aplasia (PRCA). This is a very rare condition where the body no longer makes red blood cells and the patient has severe anemia. Check with your doctor right away if you have a fever and sore throat; pale skin; unusual bleeding or bruising; or unusual tiredness or weakness.

Prograf Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Abdominal or stomach pain


• abnormal dreams


• agitation


• anxiety


• chills


• confusion


• convulsions (seizures)


• diarrhea


• dizziness


• fever and sore throat


• flu-like symptoms


• frequent urination


• headache


• infection


• itching


• loss of appetite


• loss of energy or weakness


• mental depression


• muscle trembling or twitching


• nausea


• nervousness


• pale skin


• seeing or hearing things that are not there


• shortness of breath


• skin rash


• swelling of the feet or lower legs


• tingling


• trembling and shaking of the hands


• trouble with sleeping


• unusual bleeding or bruising


• unusual tiredness or weakness


• vomiting

Less common

• Blurred vision


• chest pain


• increased sensitivity to pain


• muscle cramps


• numbness or pain in the legs


• ringing in the ears


• sweating

Rare

• Enlarged heart


• flushing of the face or neck


• general feeling of discomfort or illness


• weight loss


• wheezing

Incidence not known

• Black, tarry stools


• blistering, peeling, or loosening of the skin


• bloating


• bloody urine


• blurred vision


• constipation


• cough


• drowsiness


• fainting


• fast, slow, or irregular heartbeat


• heartburn


• increased blood pressure


• increased thirst


• indigestion


• joint or muscle pain


• lightheadedness


• loss of appetite


• lower back or side pain


• nausea


• pinpoint red spots on skin


• pounding or rapid pulse


• red, irritated eyes


• red skin lesions, often with a purple center


• shortness of breath


• skin sores


• stomach pain


• troubled breathing


• ulcers or white spots in mouth or on lips


• weakness


• weight gain


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• belching


• difficulty with moving


• lack or loss of strength


• muscle pain or stiffness


• unable to sleep

Less common

• Body aches or pain


• burning or stinging of the skin


• cracks in the skin


• crying


• delusions


• dementia


• depersonalization


• dysphoria


• euphoria


• excessive muscle tone


• feeling of constant movement of self or surroundings


• feeling that others are watching you or controlling your behavior


• feeling that others can hear your thoughts


• increased sensitivity of the skin to sunlight


• large, flat, blue or purplish patches in the skin


• loss of strength or energy


• muscle tension or tightness


• painful blisters on the trunk of the body


• painful cold sores or blisters on the lips, nose, eyes, or genitals


• paranoia


• quick to react or overreact emotionally


• rapidly changing moods


• redness or other discoloration of the skin


• restlessness


• scaly skin


• sensation of spinning


• severe mood or mental changes


• severe sunburn


• sleepiness or unusual drowsiness


• sore mouth or tongue


• sores on the skin


• swelling or inflammation of the mouth


• tender, swollen glands in the neck


• unusual behavior


• white patches in the mouth, tongue, or throat

Incidence not known

• Change in color vision


• decreased weight


• difficulty seeing at night


• feeling hot and cold


• hearing loss


• sudden sweating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

PMS-Pravastatin

PMS-Pravastatin may be available in the countries listed below.

Ingredient matches for PMS-Pravastatin

Pravastatin

Pravastatin sodium salt (a derivative of Pravastatin) is reported as an ingredient of PMS-Pravastatin in the following countries:

• Canada

International Drug Name Search

Pms-Nystatin

Generic Name: nystatin (Oral route)

nye-STAT-in

Commonly used brand name(s)

In the U.S.

• Bio-Statin

In Canada

• Mycostatin Suspension


• Nadostine


• Nadostine Sucrose-Free


• Nilstat Drops


• Nilstat Powder


• Nyaderm


• Pms-Nystatin

Available Dosage Forms:

• Capsule


• Tablet


• Suspension

Therapeutic Class: Antifungal

Chemical Class: Polyene

Uses For Pms-Nystatin

Nystatin belongs to the group of medicines called antifungals. The dry powder, lozenge (pastille), and liquid forms of this medicine are used to treat fungus infections in the mouth.

Nystatin is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, nystatin is used in certain patients with the following medical condition:

• Candidiasis, oral (fungus infection of the mouth) (prevention)

Before Using Pms-Nystatin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and has not been reported to cause different side effects or problems in children than it does in adults. However, since children up to 5 years of age may be too young to use the lozenges (pastilles) or tablets safely, the oral suspension dosage form is best for this age group.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of oral nystatin in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of nystatin

This section provides information on the proper use of a number of products that contain nystatin. It may not be specific to Pms-Nystatin. Please read with care.

For patients taking the dry powder form of nystatin:

• Add about ⅛ teaspoonful of dry powder to about 4 ounces of water immediately before taking. Stir well.


• After it is mixed, take this medicine by dividing the whole amount (4 ounces) into several portions. Hold each portion of the medicine in your mouth or swish it around in your mouth for as long as possible, gargle, and swallow. Be sure to use all the liquid to get the full dose of medicine.

For patients taking the lozenge (pastille) form of nystatin:

• Nystatin lozenges (pastilles) should be held in the mouth and allowed to dissolve slowly and completely. This may take 15 to 30 minutes. Also, the saliva should be swallowed during this time. Do not chew or swallow the lozenges whole.


• Do not give nystatin lozenges (pastilles) to infants or children up to 5 years of age. They may be too young to use the lozenges safely.

For patients taking the oral liquid form of nystatin :

• This medicine is to be taken by mouth even if it comes in a dropper bottle. If it does come in a dropper bottle, use the specially marked dropper to measure each dose accurately.


• Take this medicine by placing one-half of the dose in each side of your mouth. Hold the medicine in your mouth or swish it around in your mouth for as long as possible, then gargle and swallow.

Patients with full or partial dentures may need to soak their dentures nightly in nystatin for oral suspension to eliminate the fungus from the dentures. In rare cases when this does not eliminate the fungus, it may be necessary to have new dentures made.

To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if your condition has improved. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For the lozenge (pastille) and tablet dosage forms:
  
  • Adults and children 5 years of age and older: 1 or 2 lozenges or tablets three to five times a day for up to fourteen days.
  
  
  • Children up to 5 years of age: Children this young may not be able to use the lozenges or tablets safely. The oral suspension is better for this age group.
  
  


• For the suspension dosage form:
  
  • Adults and children 5 years of age and older: 4 to 6 milliliters (mL) (about 1 teaspoonful) four times a day.
  
  
  • For older infants: 2 mL four times a day.
  
  
  • For premature and low-birth-weight infants: 1 mL four times a day.
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the lozenge (pastille) form in the refrigerator.

Pms-Nystatin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Diarrhea


• nausea or vomiting


• stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Pms-Nystatin resources

• Pms-Nystatin Use in Pregnancy & Breastfeeding
• Drug Images
• Pms-Nystatin Drug Interactions
• Pms-Nystatin Support Group
• 3 Reviews for Pms-Nystatin - Add your own review/rating

Compare Pms-Nystatin with other medications

• Gastrointestinal Candidiasis
• Oral Thrush